Inhibiting Calpain Dependent Degradation of Desmoplakin
نویسندگان
چکیده
منابع مشابه
SORLA regulates calpain-dependent degradation of synapsin.
INTRODUCTION Sorting-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor in neurons and a major risk factor for Alzheimer disease. METHODS Here, we performed global proteome analyses in the brain of SORLA-deficient mice followed by biochemical and histopathologic studies to identify novel neuronal pathways affected by receptor dysfunction. RESULTS We demonstrat...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.2050